metavanadate diabetes

It has been highlighted that V at the highest oxidation state (+5) is the most toxic vanadium form [9]. Summary of vanadium-magnesium interactions in vivo model: our studies (I) and studies of other authors (II). In vivo and in vitro studies of vanadate in human and rodent diabetes mellitus. Matsuda M., Mandarino L., DeFronzo R.A. Synergistic interaction of magnesium and vanadate on glucose metabolism in diabetic rats. 11). Park S.J., Youn C.K., Hyun J.W., You H.J. Epidemiological studies suggest that exposure to elevated levels of V may be a risk factor for cancer development [80]. Zabolotny J.M., Haj F.G., Kim Y.B., Kim H.J., Shulman G.I., Kim J.K., Neel B.G., Kahn B.B. More details about V-containing steel and alloys, which were and still are used to produce various structural components of aircraft, weapon, rocket engines, etc., are summarized in the following table (Table 1 [197]. Bis(maltolato)oxovanadium(IV) inhibits the activity of PTP-1B in Zucker rat skeletal muscle in vivo. Berg L.R. 11). Effect of pirfenidone against vanadate-induced kidney fibrosis in rats. Since that time, more reports have appeared about the effects of co-application of V with Cr(III) [59,[269], [270], [271], [272]] or Mg [[51], [52], [53], [54], [55], [56], [57], [58],63,259,260] to rats (Fig. The investigators synthesized three new complexes of this metal (at three different oxidation levels; III, IV, and V) with Schiff base ligands showing differences in the coordination of the metal with the ligand in order to compare their physicochemical and spectroscopic properties as potential antidiabetic drugs. In addition, a new promising effect of V compounds involving oncolytic viruses and their potential to combat cancer has recently been suggested. Fatola O.I., Olaolorun F.A., Olopade F.E., Olopade J.O. 6). After entering the bloodstream, 8090 % of V is bound by albumin (ALB), which plays a pivotal role in the transport of various metals [95] or transferrin (Tf) (preferably), which is the main V transporter in the blood plasma [8,33]. 2022 Oct;35(5):903-919. doi: 10.1007/s10534-022-00413-5. Dzhurinskiy D. Bioactive antimicrobial coatings for implantable medical devices formed by plasma electrolytic oxidation. To define its efficacy and mechanism of action, 11 type 2 diabetic patients were treated with VOSO 4 at a higher dose . Diabetes Several animal studies and a few small human studies suggest that vanadium may lower blood sugar levels and improve sensitivity to insulin in people with type 2 diabetes. Antioxidant-Antidiabetic Agents and Human Health. Both Tf and ALB bind V in the 4+ and 5+ oxidation state [96]. Activation of the PI3K-Akt pathway results in the phosphorylation of endothelial nitric oxide synthase (eNOS) responsible for catalyzing nitric oxide (NO) production (Fig. Part 2: Health Effects). 13). Evangelou A.M. Vanadium in cancer treatment. 11). Etcheverry S.B., Di Virgilio A.L., Barrio D.A. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). To date, symptoms of V deficiency have been described, inter alia, in birds, chickens, rats, guinea pigs, and goats [35,38,46]. Vanadium has emerged as a possible treatment for metabolic diseases. Control nondiabetic rats were treated similarly. Curran G.L. V: vanadium, NI: normal intake. nearly 150 years after the first discovery of this metal [after 38] (Fig. Multidirectional studies on V have shown that further analyses are still required for this element to be used as a metallodrug in the fight against certain life-threatening diseases. While discussing V in terms of its medical application, it has to be mentioned that this metal is applied in tissue engineering to obtain biomaterials that allow regeneration of damaged tissues/organs and restoration of their lost functions [110]. In this study, our results revealed that NaVO3 was able to inhibit proliferation of murine breast cancer cells 4T1 with IC50 value of 8.19 M and 1.92 M at 24 h and 48 . In turn, sodium metavanadate (SMV) was administered in patients with NIDDM and in those with insulin-dependent diabetes mellitus (IDDM) by Goldfine et al. to 33]. [190,191]. 11). Diabetic rats given sodium metavanadate (0.5 mg in 0.5 ml of water by gavage twice daily; n = 8) had significantly lower food intakes ( P < 0.001) than untreated diabetic rats. Balance and tissue distribution of vanadium after short-term ingestion of vanadate. 16 For example, the results from a study conducted by Ni et al. The biological activity of this element has prompted investigations of many organic V complexes and its inorganic compounds in terms of their potential use in the treatment of certain diseases in humans. ). Dudek ., Hryniewicz T., Rokosz K. Zastosowanie tytanu i wybranych stopw tytanu w lotnictwie. Cholesterol biosynthesis pathway with probable sites of vanadium action (I) along with changes in the lipid profile in humans occupationally exposed to vanadium (II) and in diabetic patients receiving inorganic vanadium salts (III). The results from this work revealed that V complexes caused cell cycle arrest in the G2/M phase and induced a significant increase in ROS generation in a time- and concentration dependent manner. Korbecki J., Baranowska-Bosiacka I., Gutowska I., Chlubek D. Insulino-mimetyczne waciwoci zwizkw wanadu. In: Nriagu J.O., editor. Overall, the history of these studies dates back to 1995 when Cohen and co-workers [187] conducted the first trials on the effects of VS in patients with non-insulin-dependent diabetes mellitus (NIDDM). Effects of vanadium-containing compounds on membrane lipids and on microdomains used in receptor-mediated signaling. This was followed by a rediscovery of the element in 1830 by Swedish physician and chemist Nils Gabriel Sefstrm, who named it vanadium [6]. Some complexes of this element have been shown to inhibit the activity of viral reverse transcriptase (RT) [after33,123], which is responsible for the synthesis of DNA on the viral RNA matrix in the reverse transcription process facilitating integration of the viral DNA into the genome of the host cell. A reduction in the GSH/GSSG ratio [153] (Fig. Given the recent progress in the research on the pharmacological activity of different V compounds/complexes, it can be assumed that new V-based drugs will be available for therapeutic purposes in the future. Briefly, Adams research group focused on the synthesis of a new anti-diabetic complex containing vanadium(IV) and vitamin A. Kowalski Sz., Wyrzykowski D., Hac S., Rychlowski M., Radomski M.W., Inkielewicz-Stpniak I. 9). 12). In vivo studies carried out on smooth muscle (isolated from guinea pig's airways) [206] have shown that the inhibition of the activity of the sodium-potassium pump (Na+/K+-ATPase) by this element [143] does not seem to be linked to the mechanism responsible for smooth muscle contractility [206]. 7 Zaporowska H. Effect of vanadium on L-ascorbic acid concentration in rat tissues. In: Sigel H., Sigel A., editors. However, although some studies cited above reveal that supplementation with Mg during V exposure has beneficial effects reflected in reduction of the level of LPO in certain cells/tissues of healthy rats, further studies (in other animal models) have to be conducted to recognize whether the antagonistic effects of Mg on pharmacological amounts of V will allow V to exert beneficial effects, or whether their synergistic actions yield beneficial effects at lower amounts of V. Some time ago, Matsuda et al. Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus. Role of vanadium in nutrition: metabolism, essentiality and dietary consideration. It is a transition element (with atomic number 23 and relative atomic weight of 50.94) capable of forming various compounds and functioning as an anion or a cation [3]. Goldfine A.B., Patti M.E., Zuberi L., Goldstein B.J., LeBlanc R., Landaker E.J., Jiang Z.Y., Willsky G.R., Kahn C.R. aLaboratory of Oxidative Stress, Centre for Interdisciplinary Research, The John Paull II Catholic University of Lublin, Poland, bDepartment of Didactics and Medical Simulation, Chair of Anatomy, Medical University of Lublin, Poland, cDepartment of General, Oncological, and Minimally Invasive Surgery, 1 Military Clinical Hospital with the Outpatient Clinic in Lublin, Poland, dMilitary Clinical Hospital with the Outpatient Clinic in Lublin, Poland. Comprehensive research on the interactions of V with antioxidant elements (summarized graphically in a separate chapter of the present report) is particularly important in view of minimization of the adverse effects of V resulting from its strong toxicological/pro-oxidative potential. ). 13). 2 Enzyme PTP-1B Inhibition Studies by Vanadium Metal Complexes: a Kinetic Approach. National Library of Medicine 31. In: Nriagu J.O., editor. (Metal Ions in Biological Systems). Kuera J., Lener J., Mukov J., Bayerov E. Vanadium exposure tests in humans: hair, nails, blood, and urine. Their beneficial therapeutic properties have been reported and diseases of interest against which they could be effective have been suggested. De la Tore A., Granero S., Mayayo E., Corbella J., Domingo J.L. Additionally, the lack of proper industrial wastewater management containing this metal can be another risk factor for animal and human health [9,82]. [162] showed that certain multidentate oxovanadium(IV) complexes have promising anti-cancer activity against human HepG2 and SMMC-7721 hepatocellular carcinoma cells. cibior A., Adamczyk A., Mroczka R., Niedwiecka I., Gobiowska D., Fornal E. Effects of vanadium (V) and magnesium (Mg) on rat bone tissue: mineral status and micromorphology. Azarnoff D.L., Curran G.L. 31. It has also been reported that V species can enter cells via membrane citrate transporters, the lactate transporter, and the organic anion transporter (Organic-AT) [101]. Summary of the mechanisms and factors of vanadium toxicity: vanadium; LPO: lipid peroxidation; ROS: reactive oxygen species; MRC: mitochondrial respiratory chain; OXPHOS: oxidative phosphorylation; M: mitochondrion; Cyt c: cytochrome c; PARP: poly (ADP-ribose) polymerase. 11). A few years later, in 2007/08, the same V compound was used in a phase IIa trial in seven type 2 diabetic subjects [180,181] (Fig. Vol. Studies on interactions of V with Mg, which showed that both elements are able to modulate the response in an interactive manner are needed as well, as the results of such investigations may help not only in recognizing new markers of V toxicity and clarify the underlying interactive mechanism between them, thus improving the medical application of the metals against modern-age diseases, but also they may help in development of principles of effective protection of humans against environmental/occupational V exposure. It eliminates the toxins and fats in the liver and makes it healthy. Kopp S.J., Daar J., Paulson D.J., Romano F.D., Laddaga R. Effects of oral vanadyl treatment on diabetes-induced alterations in the heart GLUT-4 transporter. Thus, by inhibiting RT activity, vanadium blocks viral replication. phosphate or sulfate channels [106]. This effect results from the antagonism related to the structural similarity of vanadate anions (VO4 The aim of the study was to evaluate the short-term effects of sodium metavanadate in prediabetic BB-DP rats. The .gov means its official. Summary of positive and negative aspects of vanadium. Mol Cell Biochem. Yamaguchi M., Sishi H., Suketa Y. However, the discovery was not attributed to him. 7). Based on these findings, the authors suggested a potential role for combination therapy with trace elements in type 2 diabetes mellitus and other insulin-resistant states. The essentiality and metabolism of vanadium. The diabetes-reversing protocol also includes several miracle ingredients as below: Boden G., Chen X., Ruiz J., van Rossum G.D., Turco S. Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus. Objective Bishayee A., Chatterjee M. Time course effects of vanadium supplement on cytosolic reduced glutathione level and glutathione S-transferase activity. Bogden J.D., Higashino H., Lavenhar M.A., Bauman J.W., Kemp F.W., Aviv A. food poisoning, gastrointestinal and respiratory infections, typhoid fever, pneumonia, strep throat, tuberculosis, and skin diseases. Vanadyl sulfate (VOSO 4) is an oxidative form of vanadium that in vitro and in animal models of diabetes has been shown to reduce hyperglycemia and insulin resistance. Tytan I Jego Stopy. The mechanism of the anti-hypercholesterolemic action of V is related to the effect of this element on the cholesterol biosynthesis pathway shown in Fig. Additionally, comprehensive research on the interactions of V with other elements is needed as well (Fig. One of the compounds of this metal, vanadium pentoxide (V2O5), which contains V at the highest oxidation state +5, has been reported to easily reach the alveolar surface, subsequently enter circulation directly, and diffuse in the entire organism inducing diverse injuries [9]. There was an increase in the levels of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A (Apo-AI, main HDL apolipoprotein) in the serum and a decrease in such atherogenic indices as TC/HDL-C, LDL-C/HDL-C, and ApoB/ApoA-I [238] (Fig. Nogalska A., wierczyski J. Leptyna hormon o wielu funkcjach. In: Nriagu J.O., editor. Therefore, it would be advisable to shift the balance towards the beneficial action of V, whose pharmacological potential has repeatedly been revealed, as evidenced by the results of many studies conducted in a variety of different cell lines and in animal models. Metavanadate synonyms, Metavanadate pronunciation, Metavanadate translation, English dictionary definition of Metavanadate. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. Biophys. 31. Kordowiak A.M., Holko P. Pochodne wanadu jako zwizki o istotnym znaczeniu biologicznym. The impact of V on stimulation of the lipoprotein lipase (LPL) activity has been highlighted as well [29,236]. Studies that have examined the effect of metformin on hepatic glucose production (HGP) and muscle 7), which plays a role of a cell death promoting factor [65]. The ability of this metal to form organometallic compounds has contributed to the increase in the number of studies on the multidirectional biological activity of its various organic complexes in view of their application in medicine. 15) and thus inhibits the synthesis of neuropeptide Y (NPY) and its release in the hypothalamus. The effects depend on the metavanadate concentration and 0.2 mg/ml is preferable. Pessoa J.C., Garribba E., Santos M.F.A., Santos-Silva T. Vanadium and proteins: uptake, transport, structure, activity and function. Sanna D., Micera G., Garribba E. On the transport of vanadium in blood serum. It is also used in metallurgical industry for production of steel and non-ferrous alloys [1,9,10]. Bioinorganic Vanadium Chemistry. Glucose metabolism measured during a two-step euglycemic insulin clamp was not significantly increased by vanadate therapy in patients with IDDM, but was improved by 29% during the low dose (0.5 mU/kg.min) insulin infusion and 39% during the high dose (1.0 mU/kg.min) in patients with NIDDM. We aimed to investigate whether vanadium treatment is effective against metabolic disturbances caused by chronic exposure to the lowest-observable adverse effect level of cadmium. With regard to this issue, Sanchez et al. 289320. The site is secure. It may also weaken the antioxidant barrier [49,[51], [52], [53]] and intensify lipid peroxidation (LPO) [49,[53], [54], [55], [56], [57], [58]] i.e. Moreover, steel with V was well suited for production of armored fighting vehicles used during the Second World War [[11], [12], [13], [14], [15], [16]]. As far as application of V in diabetic patients is concerned, this may be a considerable problem and may pose a risk of toxicity, as this element is highly toxic and is able to accumulate and interact with other metals. 12). As stressed by the authors, this may point to separate metabolic pathways of these compounds in the body and a role of tridentate L Schiff base ligands. In vanadate-treated diabetic rats, blood glucose levels were significantly lower than in untreated diabetic rats ( P < 0.001). 12). The aim of the study was to evaluate the shortterm effects of sodium metavanadate in . Besides, other authors described the use of V in diabetes mellitus (DM) (Fig. A decrease in cholesterol and/or low-density lipoprotein cholesterol (LDL-C) have also been found in the serum of type II diabetes patients after 6 weeks of administration of VOSO4 [192,193] and in type I and II diabetes mellitus patients after 2-week treatment with sodium metavanadate (NaVO3) [191] (Fig. 18. A review of thirty years of research. Adriazola I.O., Evangelista do Amaral A., Amorim J.C., Correia B.L., Petkowicz C.L., Merc A.L., Noleto G.R. Cell. In: Aureliano M., editor. Yanardag R., Bolkent S., Karabulut-Bulan , Tunali S. Effects of vanadyl sulfate on kidney in experimental diabetes. ROS production is commonly known to lead to disturbance in cellular metabolism and damage to lysosomes and mitochondria (critical for maintaining cellular homeostasis) [148], resulting in activation of caspases and apoptosis [123,149,150]. 11). Altamirano-Lozano M.A., lvarez-Barrera L., Mateos-Nava R.A., Fortoul T.I., Rodrguez-Mercado J.J. Undisputed is the fact that recognition of doses of elements showing synergistic/antagonistic action towards each other may play a role in both medicine and pharmacology. orthopedic and dental implants), a surface with appropriate bioactivity and roughness is created to achieve rapid osseointegration and a durable connection between biomaterial and tissue [11]. Younes M., Strubelt O. Vanadate-induced toxicity towards isolated perfused rat livers: the role of lipid peroxidation. As suggested, the molecular mechanisms of cytotoxicity of these complexes were dependent on generation of ROS and cell cycle arrest in the G2/M phase with simultaneous activation of the p53/p21 pathway. For example, in 1987, Meyerovitch and co-investigators [179] reported that V is able to normalize the blood GLU level (in vivo model) (Fig. In turn, higher concentrations of V in the soil lead to more intensive uptake of this metal being by plants due to the lack of a selective mechanism protecting plants against excessive absorption of the element. 10 Bookshelf Thus, the toxicity of V that could derive from the chronic treatment with this element is of particular concern. It has been suggested that the antioxidative effects of pyruvate, especially its ability to neutralize hydrogen peroxide, may be involved in the observed mechanism of protection. The most common adverse effect of oral NaVO3 was mild gastrointestinal intolerance. Vanadium compounds discriminate hepatoma and normal hepatic cells by differential regulation of reactive oxygen species. Sobociska M., Kamysz E. Potencjalne zastosowanie enkefalin w diagnostyce i terapii rnych chorb. 1991 Apr;72(4):801-7. doi: 10.1210/jcem-72-4-801. In 1996, Halberstam et al. The age of onset of diabetes was significantly higher for groups V2, V3 compared to group C, (p < 0.05) and depends on the metavanadate concentration (V3 vs. V1, p=0.006). As illustrated in Fig. Based on available literature data cited in section 5.1 and other reports; after [33], **after [38], after [39], *after [40], ##after [41]. Due to its multidirectional biological activity and a wide range of effects on the mammalian organism, vanadium has been arousing interest of many research centers worldwide for many years. 8600 Rockville Pike V: vanadium, N: nitrogen, V-BrPO: vanadium bromoperoxidase. John Wiley and Sons; New York, Chichester, Weinheim, Brisbane, Singapore, Toronto: 1998. pp. Much attention is still focused on studies of the design of V compounds for cancer treatment, as evidenced by recently published articles. Younes M., Kayser E., Strubelt O. The https:// ensures that you are connecting to the Synergy has also been determined for such roughness parameters as (d) mean roughness (Sa) and (e) root mean square roughness (Sq) (Fig. The use of this metal in medicine is of particular concern.

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